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|WikiProject Pharmacology||(Rated Start-class, Mid-importance)|
- 1 Over the counter availability... ?
- 2 Protein Binding
- 3 Drat!
- 4 Vetinary Use
- 5 photosensitivity reactions after applications of topical Ketoprofen formulations (in combination with octocrylene)
- 6 Post-surgery pain-killer
- 7 Disposal versus Disposition
- 8 Should add cardiac side effect as in diclofenac
Over the counter availability... ?
Is it still available over the counter? The reason I started to get it by prescription is because I haven't been able to procure it over the counter. Can anyone shed some light on this? Thanks. Alex 08:02, 4 November 2005 (UTC)
Ketoprofen is no longer available in the U.S. in 12.5 mg non-prescription strength. Orudis KT had difficulty competing against generic ibuprofen even before the new black box warnings on NSAIDS. It is finally becoming available again in oral form by prescription in 25, 50, 75, and 200 mg dosages. It is often still difficult to get, mention to the pharmacist that Mylan distributes it now.
Is that figure correct? One wonders how it even works with 99% bound to protein --18.104.22.168 05:54, 4 December 2006 (UTC)
- Yes, it is correct. Pretty much drugs have almost a 100% plasmatic proteine bound, yet still they are working; the bound to plasma proteins isn't irreversible.--22.214.171.124 16:59, 20 April 2007 (UTC)
That stinks that it is no longer available over the counter. I just used my last tablet yesterday. I suppose if I only had to purchase a bottle every 3 years, they could not have been selling too many of them.
126.96.36.199 19:57, 18 December 2006 (UTC)
- Sadly, it worked too well. Can't have something more effective than prescription meds available OTC now, can we? --Snicker|°| 12:39, 22 February 2007 (UTC)
- In Europe we have e.g. Naproxen in 200/250 mg tabs. available OTC -- quite a good NSAID, too. Isn't it Aleve in the US..?--188.8.131.52 20:25, 20 April 2007 (UTC)
I know that this is used in vetinary settings a fair bit under the name Ketofen. Can't find too many decent references that aren't trying to sell it though. If anyone can come up with some, I think it'd be a good addition to the article 184.108.40.206 14:29, 26 May 2007 (UTC)
- To look at the contents list of the article you would get the impression that it is only used for vetinary purposes. Everything is under the heading Use in horses and other animals. --ChrisSteinbach (talk) 16:49, 28 June 2008 (UTC)
photosensitivity reactions after applications of topical Ketoprofen formulations (in combination with octocrylene)
see: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Ketaprofen_107/WC500094971.pdf — Preceding unsigned comment added by Herwigneefs (talk • contribs) 07:32, 30 December 2010 (UTC)
Disposal versus Disposition
'Disposition' has nothing to do with the disposing of something; it is a noun that refers to a person's inherent qualities of mind and character, or an inclination. E.g. 'he has a temperamental disposition'. Therefore it must remain 'disposal' in the article. — Preceding unsigned comment added by 220.127.116.11 (talk) 11:32, 30 September 2012 (UTC)
Should add cardiac side effect as in diclofenac
Cardiac Following the identification of increased risks of heart attacks with the selective COX-2 inhibitor rofecoxib in 2004, attention has focused on all the other members of the NSAIDs group, including diclofenac. Research results are mixed, with a meta-analysis of papers and reports up to April 2006 suggesting a relative increased rate of heart disease of 1.63 compared to nonusers. Professor Peter Weissberg, Medical Director of the British Heart Foundation said, "However, the increased risk is small, and many patients with chronic debilitating pain may well feel that this small risk is worth taking to relieve their symptoms". Only aspirin was found not to increase the risk of heart disease; however, this is known to have a higher rate of gastric ulceration than diclofenac. A subsequent large study of 74,838 users of NSAIDs or coxibs found no additional cardiovascular risk from diclofenac use. A very large study of 1,028,437 Danish users of various NSAIDs or coxibs found the "Use of the nonselective NSAID diclofenac and the selective cyclooxygenase-2 inhibitor rofecoxib was associated with an increased risk of cardiovascular death (odds ratio, 1.91; 95% confidence interval, 1.62 to 2.42; and odds ratio, 1.66; 95% confidence interval, 1.06 to 2.59, respectively), with a dose-dependent increase in risk." In Britain the Medicines and Healthcare Products Regulatory Agency (MHRA) said in June 2013 that the drug should not be used by people with serious underlying heart conditions—people who had suffered heart failure, heart disease or a stroke were advised to stop using it completely. --Adriano G. V. Esposito (talk) 06:06, 9 March 2014 (UTC)